New Tetrahydroquinoline Antibiotic from Janibacter limosus Hel
نویسندگان
چکیده
The ethyl acetate extract of cultures of Janibacter limosus showed a high biological activity against bacteria, and fungi and delivered two new natural products, a tetrahydroquinoline derivative designated as helquinoline (1), and the N-acetylkynuramine (3a), along with other known secondary metabolites. The structure of 1 has been elucidated as 4-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid on the basis of 1D and 2D NMR and mass spectra. The relative stereochemistry of the compound 1 was assigned as 2R,4R with the aid of coupling constants, NOESY correlation and by comparison with a related compound.
منابع مشابه
J. Gen. Appl. Microbiol., 53, 185–189 (2007)
The genus Janibacter was proposed by Martin et al. (1997) with the type species Janibacter limosus. The genus Janibacter belongs to the family Intrasporangiaceae in the order Actinomycetales. There are currently four species in the genus Janibacter : Janibacter limosus (Martin et al., 1997), Janibacter terrae (Yoon et al., 2000), Janibacter melonis (Yoon et al., 2004) and Janibacter anophelis (...
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